MASSACHUSETTS – August 29, 2023 – KACTUS, the industry’s leader in recombinant protein and enzyme products, announces the launch of SAMS™ (Structure Aided Multiplex Screening), its cutting-edge proprietary protein engineering and expression optimization platform to optimize high activity and purity of difficult-to-express protein targets.
The SAMS™ platform leverages advanced bioinformatics, 3D modeling, and expression testing to address the challenges associated with producing complex proteins. The KACTUS team of experts employs bioinformatics and structural analysis to design various protein sequences and structures based on key variables such as signal peptides, codons, and vectors. Each protein construct is optimized based on host cell selection, purification methods, expression conditions, and storage conditions.
“Through the SAMS platform, we have already produced multiple challenging proteins, including the first-ever full-length Claudin 18.2 protein.,” said Dr. ManHee Suh, Chief Technology Officer at KACTUS.
Researchers face a plethora of common challenges while working with recombinant proteins, encompassing issues like membrane protein antigen production, recombinant antigen immunogenicity, antibody affinity, batch-to-batch consistency, production time, and production cost. Kactus’ SAMS™ system is poised to alleviate these challenges with its high-throughput protein engineering and expression screening capabilities, ensuring remarkable activity and purity even with the most challenging targets.
The SAMS™ platform opens a gateway to an array of customized recombinant protein production services, including but not limited to MHC Complexes, VLP-Displayed Antigens, CRISPR Enzymes, and other elusive proteins that are notoriously difficult to express. By leveraging SAMS™, researchers can overcome these challenges resulting in accelerated advancements and breakthroughs in their respective fields.
The distinctive power of SAMS™ lies in its intricate methodology that seamlessly integrates bioinformatics, 3D modeling, and expression testing. This proprietary approach identifies unmet needs for commercial proteins through accurate literature and database searches. Subsequently, bioinformatics and structural analysis are harnessed to design diverse protein sequences and structures, meticulously considering variables from the structural hierarchy. The critical factors like integrity, signal peptide, and codons are subjected to rigorous scrutiny using structural informatics and 3D modeling to gauge their impact on all tiers of protein structure.
The optimal protein configuration emerges from extensive exploration of protein configurations and expression conditions. This configuration prioritizes natural conformation, yielding, and bioactivity. To guarantee reliability, protein designs undergo exhaustive bioactivity testing across multiple cell types and settings, affirming that the purchased protein is primed to excel in its intended application.
The SAMS™ platform’s manifold advantages include:
Individual structure-based antigen design
Native antigen conformation mimicry
Optimized expression ensuring high purity and yield
Augmented immunogenicity and bioactivity
Low endotoxin levels and superior stability
Consistency across batches
KACTUS showcased its SAMS™ platform during the BIO International Convention and PEGS Summit that took place in May and June 2023.
For inquiries, information, and collaboration opportunities, visit https://kactusbio.com/pages/sams and request custom services powered by SAMS™.
About KACTUS
KACTUS (kactusbio.com) is a leading biotechnology company specializing in the design and production of custom recombinant proteins and enzymes. KACTUS’ advanced technologies like SAMS™, and a comprehensive catalog selection of 2500+ ready-made recombinant proteins including various targets, species, tags, and labels, help advance antibody drug discovery, immunotherapy, gene therapy, and mRNA therapeutics through superior protein engineering.
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KACTUS
Vincent Wu
Vice President, US Operations
888-466-3604
[email protected]
www.kactusbio.com
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Media ContactCompany Name: KACTUS Contact Person: Vincent WuEmail: Send EmailCountry: United StatesWebsite: https://kactusbio.com/
